Glucocorticoid regulation of transcription at an amplified, episomal promoter.

Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter.

Glucocorticoid hormones alter transcription of specific genes. Glucocorticoid-stimulated genes have been especially useful in unraveling molecular events responsible for positive gene regulation in mammals. The gene encoding proopiomelanocortin (POMC), which is under feedback inhibition by glucocorticoids, provides a model system to study negative gene regulation. Using an episomal bovine papil...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

down regulation of dhfr promoter activity by pml transcription repressor

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Glucocorticoid down-regulation of rat glucocorticoid receptor does not involve differential promoter regulation.

The level of expression of the glucocorticoid receptor (GR) is the principal determinant of glucocorticoid sensitivity in most cells. GR levels are permanently 'set' in a tissue-specific manner in response to the perinatal environment, an effect we have previously shown to relate to differential expression of tissue-enriched alternative promoters/exons 1 of the GR gene. In adult animals, GR lev...

Negative regulation of interleukin 2 transcription by the glucocorticoid receptor

Glucocorticoid-dependent transcriptional enhancement is known to occur through the interaction of the glucocorticoid receptor (GR) with specific DNA response elements. In contrast, negative regulation of gene expression by this class of hormone is less well understood. Glucocorticoids are potent immunosuppressive agents acting primarily by inhibiting T lymphocyte activation and lymphokine produ...